The draw third round draw which held on Monday will see the Gunners face the Magpies for the first time since they last met in January 2008.
Last season finalist Chelsea will begin their campaign against League two side Morecambe.
It will be the first ever meeting with Morecambe who are currently 15th in their division.
The ties are to take place across the weekend of 8 to 11 January, with the exact dates to be announced in due course.
Mohamed Salah will go head to head against his Egyptian teammate Trezeguet as Liverpool travel to face Aston Villa.
The full draw, which includes Tottenham visiting eighth-tier non-league side Marine, all-Premier League ties between Wolves and Palace, Villa and Liverpool, and a west London derby with QPR hosting Fulham.
FA CUP THIRD ROUND FULL DRAWS
Huddersfield Town vs Plymouth Argyle
Southampton vs Shrewsbury Town
Chorley vs Derby County
Marine vs Tottenham
Wolverhampton Wanderers vs Crystal Palace
Stockport County vs West Ham United
Oldham Athletic vs AFC Bournemouth
Manchester United vs Watford
Stevenage vs Swansea City
Everton vs Rotherham United
Nottingham Forest vs Cardiff City
Arsenal vs Newcastle United
Barnsley vs Tranmere Rovers
Bristol Rovers vs Sheffield United
Canvey Island/Boreham Wood vs Millwall
Blackburn Rovers vs Doncaster Rovers
Stoke City vs Leicester City
Wycombe Wanderers vs Preston North End
Crawley Town vs Leeds United
Burnley vs Milton Keynes Dons
Bristol City vs Portsmouth
Queens Park Rangers vs Fulham
Aston Villa vs Liverpool
Brentford vs Middlesbrough
Manchester City vs Birmingham City
Luton Town vs Reading
Chelsea vs Morecambe
Exeter City vs Sheffield Wednesday
Norwich City vs Coventry City
Blackpool vs West Bromwich Albion
Newport County vs Brighton and Hove Albion
Cheltenham Town vs Mansfield Town