The Super Eagles will be without Kevin Akpoguma when they face the Djurtus of Guinea Bissau on Monday.
The German-based defender started the first leg match at the MKO Abiola stadium in Abuja before being substituted by Semi Ajayi early in the second half due to a facial injury.
Akpoguma did not attend the team’s final practice on Saturday and will most likely be sidelined for the vital encounter.
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Guinea Bissau defeated Super Eagles 1-0 at home to take the lead in Group A with seven points, while Super Eagles had four.
Nigeria’s victory on Monday will return them to the top of the table and bring them closer to the competition in Ivory Coast.