Lesotho and Malawi start their Hollywoodbets Cosafa Cup journey when they meet in South Africa on Wednesday afternoon.
The Group B match will take place at King Zwelithini Stadium in Durban where Eswatini beat Mauritius 3-0 in an early kick-off.
Group stage games involve lowly ranked eight teams split into two groups.
The overall winner of each group will qualify for the quarterfinal stage to join seeded South Africa, Senegal, Namibia, Mozambique and Zambia, among others.
The biggest tournament for teams in Southern Africa started on Tuesday when Angola saw off Comoros 3-1 whereas Botswana dispatched Seychelles 1-0 in group A clashes.
Lesotho: Tsepo Moerane, Motlomelo Mkwanazi, Basia Makepe, Lisema Lebokollane, Kopano Tseka, Motebang Sera, Katleho Makateng, Thabang Malane, Jane Thabantso, Rethabile Rasethuntsa, Thabo Mafatle.
Malawi: Ernest Kakhobwe, Stanley Sanudi, Precious Sambani, Sankhani Mkandawire, Chikoti Chirwa, Chimwemwe Idana, Stenie Davie, Gabadinho Mhango, John Banda, Blessings Mpokera, Khuda Myaba